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Science 19 October 1973:
Vol. 182. no. 4109, pp. 293 - 295
DOI: 10.1126/science.182.4109.293
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Articles

Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine Receptors

Douglas M. Fambrough 1, Daniel B. Drachman 2, and S. Satyamurti 2

1 Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
2 Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

The number of acetylcholine receptors was determined in the neuromuscular junctions of eight patients with typical myasthenia gravis and in five controls, by means of 1251-labeled agr-bungarotoxin binding. The junctional acetylcholine receptors were reduced in the myasthenic muscles as compared with the controls. This reduction in receptors may account for the defect in neuromuscular transmission in myasthenia gravis.


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