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Science 5 October 1973:
Vol. 182. no. 4107, pp. 79 - 81
DOI: 10.1126/science.182.4107.79
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Articles

Nerve Growth Factor: Relationship to the Cyclic AMP System of Sensory Ganglia

Daniel B. Hier 1, Barry G. W. Arnason 2, and Michael Young 3

1 Departments of Biological Chemistry and Medicine, Harvard Medical School, and Massachusetts General Hospital, Boston 02114
2 Department of Neurology, Harvard Medical School, and Massachusetts General Hospital
3 Departments of Biological Chemistry and Medicine, Harvard Medical School, and Massachusetts General Hospital

Nerve growth factor and N6,O2' dibutyryl adenosine 3',5'-monophosphate both stimulate neurite elongation by explanted ganglia. However, the addition of nerve growth factor does not lead to increased amounts of adenosine 3',5'-monophosphate in intact ganglia, nor does it stimulate adenylate cyclase activity in broken ganglia cells.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)