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Science 28 September 1973:
Vol. 181. no. 4106, pp. 1253 - 1256
DOI: 10.1126/science.181.4106.1253
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Articles

Thyroid Hormone Action: A Cell-Culture System Responsive to Physiological Concentrations of Thyroid Hormones

Herbert H. Samuels 1, Jir S. Tsai 1, and Raquel Cintron 1

1 Endocrine Division, Department of Medicine, New York University School of Medicine, New York 10016

Cells from a rat pituitary tumor cell line will respond in vitro to physiological concentrations of L-thyroxine and L-triiodothyronine. The cells are grown in a cultutre medium that contains serum from a hypothyroid calf. Dose-response relationships of a vacriety of thyronine derivatives indicate that this system has a specificity of response which is similar to that observed in vitro.


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