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Science 21 September 1973:
Vol. 181. no. 4105, pp. 1176 - 1178
DOI: 10.1126/science.181.4105.1176
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Articles

Spontaneous Whole Brain Slow Potential Changes during Recovery from Experimental Neurosurgery

Don A. Irwin 1, Hugh E. Criswell 1, and Jan W. Kakolewski 2

1 Department of Psychology, Southern Illinois University, Carbondale 62901
2 Department of Physiology and Pharmacology, University of South Dakota Medical School, Vermillion

Prolonged, nonlocalized brain slow potential changes, frequently associated with cortical spreading depression, occur spontaneously during 5 days following brain implant surgery in rats. These potentials are accompanied by reductions in multiple nerve cell activity and reductions in behavioral motility. The method used in this study provides a tool for evaluating recovery from neurosurgical trauma or other brain injuries, and for testing procedures that facilitate or impede this process.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)