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Science 14 September 1973:
Vol. 181. no. 4104, pp. 1057 - 1058
DOI: 10.1126/science.181.4104.1057
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Articles

Breast Cancer: Induction of Differentiation by Embryonic Tissue

Jerome J. DeCosse 1, Carol Lynn Gossens 1, Joseph F. Kuzma 1, and Brian R. Unsworth 2

1 Departments of Surgery and Pathology, Medical College of Wisconsin, Milwaukee County General Hospital, Milwaukee 53226
2 Department of Biology, Marquette University, Milwaukee, Wisconsin 53233

A mouse mammary tumor, adenocarcinoma BW 10232, was maintained in vitro for 14 days, separated from embryonic mammary mesenchyme by a Millipore filter. Tubules developed in the tumor; deoxyibonucleic acid synthisis declined; and a presumptive acid mucopolysaccharide matrix, not evident in the controls, appeared.


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