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Science 31 August 1973:
Vol. 181. no. 4102, pp. 872 - 873
DOI: 10.1126/science.181.4102.872
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Articles

Genetic Control of Susceptibility to Experimental Allergic Encephalomyelitis in Rats

David L. Gasser 1, Carol M. Newlin 2, Joy Palm 3, and Nicholas K. Gonatas 4

1 Department of Human Genetics, University of Pennsylvania, Philadelphia 19174
2 Department of Biochemistry, University of Pennsylvania
3 Wistar Institute of Anatomy and Biology
4 Division of Neuropathology, Department of Pathology, University of Pennsylvania School of Medicine

Rats of the inbred strains Lewis and DA are highly susceptible to the induction of experimental allergic encephalomyelitis (EAE) while Brown Norway rats are resistant to this disease. Evidence has been obtained which suggests that a single dominant gene is associated with susceptibility to EAE. The locus controlling EAE susceptibility is closely linked to the Ag-B histocompatibility locus but is not identical to it.


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