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Science 24 August 1973:
Vol. 181. no. 4101, pp. 760 - 761
DOI: 10.1126/science.181.4101.760
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Articles

Prostaglandin Involvement in Hypothalamic Control of Gonadotropin and Prolactin Release

P. G. Harms 1, S. R. Ojeda 1, and S. M. McCann 1

1 Department of Physiology, Southwestern Medical School, University of Texas Health Science Center, Dallas 75235

Prostaglandin E2 (PGE2) injected into the third ventricle of ovariectomized rats increased plasma luteinizing hormone dramatically and follicle stimulating hormone slightly. PGE1 elevated prolactin; PGF1agr or PGF2agr had no effect. PGE2 or PGE1 injected directly into the anterior pituitary were ineffective. These results suggest that specific prostaglandins act at the hypothalamus to control pituitary hormone release.


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