Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 August 1973:
Vol. 181. no. 4101, pp. 757 - 758
DOI: 10.1126/science.181.4101.757
Prev | Table of Contents | Next

Articles

Distal Conformation of the Thyroid Hormone 3,5,3'-Triiodo-L-Thyronine

Vivian Cody 1 and William L. Duax 1

1 Molecular Biophysics Department, Medical Foundation of Buffalo, Buffalo, New York 14203

In the crystal structure of the thyroid hormone, 3,5,3'-triiodo-L-thyronine, the 3' iodine is observed in the distal position, away from the alaninebearing ring of the thyroid hormone. This result had been anticipated from stereochemical and biological activity studies. However, previous observations of structures in which the 3' iodine was proximal had cast some doubt on the stability of the 3' distal conformation. This observation suggests that the relative energies of the two conformers is similar and that perhaps the barrier to rotation is not as great as previously supposed since both the distal and proximal conformers have now been observed in the solid state.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)