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Science 24 August 1973:
Vol. 181. no. 4101, pp. 751 - 752
DOI: 10.1126/science.181.4101.751
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Articles

Differences in Collagen Metabolism between Normal and Osteoarthritic Human Articular Cartilage

Marcel Nimni 1 and Kalindi Deshmukh 1

1 Rheumatic Disease Section, Departments of Medicine and Biochemistry, University of Southern California School of Medicine, Los Angeles 90033

Normal human articular cartilage synthesizes only one type of a chain, which exhibits the chromatographic behavior of the agrl(II) chains described for chick and bovine cartilage. Osteoarthritic cartilage, on the other hand, synthesizes in addition a collagen containing agr2 chains and beta components. The different structural features of the two types of collagen may account for some of the functional defects of osteoarthritic cartilage.


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Regulation of Human COL2A1 Gene Expression in Chondrocytes. IDENTIFICATION OF C-Krox-RESPONSIVE ELEMENTS AND MODULATION BY PHENOTYPE ALTERATION.
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A Composite Element Binding the Vitamin D Receptor and the Retinoic X Receptor alpha Mediates the Transforming Growth Factor-beta Inhibition of Decorin Gene Expression in Articular Chondrocytes.
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SP3 Represses the SP1-mediated Transactivation of the Human COL2A1 Gene in Primary and De-differentiated Chondrocytes.
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