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Science 17 August 1973:
Vol. 181. no. 4100, pp. 665 - 667
DOI: 10.1126/science.181.4100.665
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Articles

Murine C-type RNA Virus from Spontaneous Neoplasms: in vitro Host Range and Oncogenic Potential

Robert L. Peters 1, Gerard J. Spahn 1, Louise S. Rabstein 1, Gary J. Kelloff 2, and Robert J. Huebner 2

1 Microbiological Associates, Inc. Walkersville, Maryland 21793
2 Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014

Strain BALB/c mice harbor at least two host range variants of marine leukemia virus. One variant, which is host-cell tropic, is the predominant isolate from neoplastic tissues and produced lymphoreticular neoplasms when injected into BALB/c newborn mice. A second variant, whicht is isolated throughout life, grows poorly in host embryonic cells in culture and was not associated with lymphoreticular neoplasm induction when injected into newborn BALB/c mice.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Endogenous Primate and Feline Type C Viruses.
G. J. Todaro, R. E. Benveniste, R. Callahan, M. M. Lieber, and C. J. Sherr (1974)
Cold Spring Harb Symp Quant Biol 39, 1159-1168
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Science. ISSN 0036-8075 (print), 1095-9203 (online)