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Science 10 August 1973:
Vol. 181. no. 4099, pp. 569 - 570
DOI: 10.1126/science.181.4099.569
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Articles

Progesterone-Dependent Messenger RNA: Heterospecific Activity in vivo

Sheldon J. Segal 1, Rufus O. Ige 1, Pentti Tuohimaa 1, and Mario H. Burgos 1

1 Population Council, Rockefeller University, New York 10021

The action of progesterone in mediating the synthesis of avidin by the chick oviduct can be simulated by the intraoviductal instillation of nitrocellulose-trapped RNA from hormonally prepared chick or pigeon oviduct. Similarly, the pigeon oviduct synthesizes avidin in response to chick oviduct RNA. Thus, a heterospecific transfer of hormonal stimulation, through the transfer of progesterone-induced RNA, is demonstrated. The biological activity is lost after digestion by pancreatic ribonuclease. The 50-fold purification achieved by nitrocellulose chromatography of the total RNA preparation suggests that the activity resides in a messenger RNA fraction.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)