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Science 3 August 1973:
Vol. 181. no. 4098, pp. 456 - 457
DOI: 10.1126/science.181.4098.456
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Articles

6-Hydroxydopamine: Evidence for Superoxide Radical as an Oxidative Intermediate

Richard E. Heikkila 1 and Gerald Cohen 1

1 Department of Neurology, College of Physicians & Surgeons of Columbia University, 640 West 168 Street, New York 10032

Superoxide dismutase inhibited the autoxidation of 6-hydroxydopamine as measured by the rate of formation of a quinone and the rate of oxygen consumption. These observations demonstrate the formation of the superoxide radical during the autoxidation process. This finding may be relevant to the mechanism of adrenergic nerve terminal degeneration caused by 6-hydroxydopamine.


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