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Science 3 August 1973:
Vol. 181. no. 4098, pp. 448 - 449
DOI: 10.1126/science.181.4098.448
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Articles

Virus-Free Adenocarcinoma of the Frog (Summer Phase Tumor) Transcribes Lucké Tumor Herpesvirus-Specific RNA

William Collard 1, Helen Thornton 1, Merle Mizell 2, and Maurice Green 3

1 Institute for Molecular Virology, St. Louis University School of Medicine, St. Louis, Missouri 63110
2 Chapman H. Hyams III Laboratory of Tumor Cell Biology, Tulane University, New Orleans, Louisiana 70118
3 Institute of Molecular Virology, St. Louis University School of Medicine

[3H]RNA isolated from "virus-free," summer phase, renal adenocarcinomas of Rana pipiens labeled with [3H]uridine hybridizes with DNA of herpesvirus particles isolated from the winter phase Lucké tumor. Transcription of the herpesvirus genome in virus-free tumors provides additional evidence for the viral etiology of this tumor.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)