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Science 3 August 1973:
Vol. 181. no. 4098, pp. 443 - 444
DOI: 10.1126/science.181.4098.443
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Articles

Superinduction of Endogenous Type C Virus by 5-Bromodeoxyuridine from Transformed Mouse Clones

M. M. Lieber 1, D. M. Livingston 1, and G. J. Todaro 1

1 Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014

Certain transformed subclones of the mouse cell line BALB/3T3 release 5 to 15 times more type C virus per cell than the parent cell line after treatment with 5-bromodeoxyuridine. Virus release begins within 8 hours and exponentially increases for the first 24 to 48 hours. Superinducibility is associated with the transformed phenotype.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mechanism of Induction of RNA Tumor Viruses by Halogenated Pyrimidines.
P. Besmer, D. Smotkin, W. Haseltine, H. Fan, A. T. Wilson, M. Paskind, R. Weinberg, and D. Baltimore (1974)
Cold Spring Harb Symp Quant Biol 39, 1103-1107
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