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Science 15 June 1973:
Vol. 180. no. 4091, pp. 1183 - 1185
DOI: 10.1126/science.180.4091.1183
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Articles

Complement-Induced Platelet Protein Alterations

Theodore S. Zimmerman 1 and Hans J. Müller-Eberhard 1

1 Scripps Clinic and Research Foundation, La Jolla, California 92037

Polypeptides of high molecular weight are deleted from the sedimentable fraction of platelets subjected, while intact, to complement action. These polypeptides, distinct from the previously described thrombin-sensitive protein of this fraction, also diminish after platelets are exposed to thrombin. They may be of importance in the molecular events underlying complement-triggered changes in platelet function.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)