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Science 8 June 1973:
Vol. 180. no. 4090, pp. 1074 - 1075
DOI: 10.1126/science.180.4090.1074
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Articles

Estrogen Formation by the Isolated Perfused Rhesus Monkey Brain

F. Flores 1, F. Naftolin 1, K. J. Ryan 1, and R. J. White 2

1 Department of Obstetrics and Gynecology, School of Medicine, University of California, San Diego, La Jolla 92037
2 Department of Neurosurgery, Case Western Reserve University School of Medicine at Cleveland Metropolitan General Hospital, Cleveland, Ohio 44109

Perfusion of two isolated brains from immature male rhesus monkeys with [3H]androstenedione resulted in the identification of free and conjugated [3H]estrone and free [3H]estradiol from the perfusates. In the dissected cerebral tissues, estrogens were recovered only from the hypothalamus and limbic system. The production of estrogens from androstenedione during the 40-minute perfusions in these two experiments totaled 1.58 and 2.83 nanograms.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)