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Science 1 June 1973:
Vol. 180. no. 4089, pp. 972 - 974
DOI: 10.1126/science.180.4089.972
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Articles

Molecular Relatedness of Mammalian RNA Tumor Viruses as Deternined by DNA · RNA Hybridization

Daniel K. Haapala 1 and Peter J. Fischinger 1

1 Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014

Each of six mammalian C-type viruses—including two feline leukemia viruses, three murine leukemia viruses, and the human "candidate" virus RD-114—can be distinguished from each other by hybridizing DNA synthesized by viral reverse transcriptase with viral RNA. Characterization of the DNA · RNA hybrids by hydroxylapatite chromatography revealed nucleotide sequence diversity among the viruses, detectable both by the amount of cross-hybridization and by the decreased thermal stability of heterologous hybrids.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Elimination of the sarcoma genome from murine sarcoma virus transformed cat cells.
A. Frankel, D. Haapala, R. Neubauer, and P. Fischinger (1976)
Science 191, 1264-1266
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Qualitative and Quantitative Studies of AKR-type Murine Leukemia Virus Sequences in Mouse DNA.
S. K. Chattopadhyay, D. R. Lowy, N. M. Teich, A. S. Levine, and W. P. Rowe (1974)
Cold Spring Harb Symp Quant Biol 39, 1085-1101
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Science. ISSN 0036-8075 (print), 1095-9203 (online)