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Science 25 May 1973:
Vol. 180. no. 4088, pp. 872 - 875
DOI: 10.1126/science.180.4088.872
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Articles

Thyrotropin and Cyclic Nucleotide Effects on Prostaglandin Levels in Isolated Thyroid Cells

Gerald Burke 1, Lin-Lin Chang 1, and Marta Szabo 1

1 Department of Medicine, Michael Reese Hospital, and University of Chicago Pritzker School of Medicine, Chicago, Illinois 60616

Thyrotropin increases prostaglandin levels in isolated thyroid cells. Since comparable results were obtained with butyrated cyclic adenosine monophosphate derivatives as well as with the phosphodiesterase inhibitors quazodine and theophylline, it appears that cyclic adenosine monophosphate mediates this effect of thyrotropin. These observations suggest that intracellular prostaglandins play a role in modulating thyrotropin action on thyroid.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)