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Science 18 May 1973:
Vol. 180. no. 4087, pp. 743 - 745
DOI: 10.1126/science.180.4087.743
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Articles

Mucopolysaccharides: Comparison of Chondroitin Sulfate Conformations with Those of Related Polyanions

Struther Arnott 1, J. M. Guss 1, D. W. L. Hukins 1, and M. B. Mathews 2

1 Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907
2 Departments of Pediatrics and Biochemistry, La Rabida-University of Chicago Institute, and Joseph P. Kennedy, Jr., Mental Retardation Research Center, University of Chicago, Chicago, Illinois 60637

X-ray diffraction shows that chondroitin 6-sulfate, and some further rulfated derivatives, can occur in two ordered structures in stretched films. Both structures contain single helices with similar projected disaccharide lengths (9.6 and 9.8 angstroms) but with very different turn angles between successive disaccharides (120 and 45 degrees). In contrast, coaxial double helices of hyaluronates and t-carrageenates have shorter projected disaccharide lengths (8.5 and 8.9 angstroms).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Glycosaminoglycan conformation: do aqueous molecular dynamics simulations agree with x-ray fiber diffraction?.
A. Almond and J. K. Sheehan (2000)
Glycobiology 10, 329-338
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