Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 4 May 1973:
Vol. 180. no. 4085, pp. 511 - 513
DOI: 10.1126/science.180.4085.511
Prev | Table of Contents | Next

Articles

Brain Aluminum Distribution in Alzheimer's Disease and Experimental Neurofibrillary Degeneration

D. R. Crapper 1, S. S. Krishnan 2, and A. J. Dalton 3

1 Departments of Physiology and Medicine, University of Toronto, Toronto 5, Ontario, Canada
2 Departments of Physiology and Medicine, University of Toronto, and Center for Forensic Sciences, Toronto
3 Department of Psychology, Mental Retardation Center, Toronto

Neurofibrillary degeneration is an important pathological finding in senile and presenile dementia of the Alzheimer type. Experimentally, aluminum induces neurofibrillary degeneration in neurons of higher mammals. Aluminum concentrations approaching those used experimentally have been found in some regions of the brains of patients with Alzheimer's disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Possible peripheral markers for chronic aluminium toxicity in Wistar rats.
A. Kaur and K. D. Gill (2006)
Toxicology and Industrial Health 22, 39-46
   Abstract »    PDF »
Aluminum, Alzheimer's Disease and the Geospatial Occurrence of Similar Disorders.
D. P. Perl and S. Moalem (2006)
Reviews in Mineralogy and Geochemistry 64, 115-134
   Full Text »    PDF »
Aluminum as a toxicant.
A Becaria, A Campbell, and S. Bondy (2002)
Toxicology and Industrial Health 18, 309-320
   Abstract »    PDF »
Aluminum Increases Levels of {beta}-Amyloid and Ubiquitin in Neuroblastoma But Not in Glioma Cells.
A. Campbell, A. Kumar, F. G. La Rosa, K. N. Prasad, and S. C. Bondy (2000)
Experimental Biology and Medicine 223, 397-402
   Abstract »    Full Text »    PDF »
Disturbance of cerebral function in people exposed to drinking water contaminated with aluminium sulphate: retrospective study of the Camelford water incident.
P. Altmann, J. Cunningham, U. Dhanesha, M. Ballard, J. Thompson, and F. Marsh (1999)
BMJ 319, 807-811
   Abstract »    Full Text »
Neurobehavioral Alteration in Rodents Following Developmental Exposure To Aluminum.
E. Alleva, J. Rankin, and D. Santucci (1998)
Toxicology and Industrial Health 14, 209-221
   Abstract »    PDF »
Pharmacotherapy of Cognitive Impairment in Alzheimer's Disease: A Review.
S. V. Patel (1995)
J Geriatr Psychiatry Neurol 8, 81-95
   Abstract »    PDF »
Neurologic Syndrome in 25 Workers From an Aluminum Smelting Plant.
D. M. White, W. T. Longstreth Jr, L. Rosenstock, K. H. J. Claypoole, C. A. Brodkin, and B. D. Townes (1992)
Arch Intern Med 152, 1443-1448
   Abstract »    PDF »
The Health Effects of Aluminium -- A Review.
K. Cooke and M.H. Gould (1991)
Perspectives in Public Health 111, 163-168
   Abstract »
Distributions of Elements in the Human Retinal Pigment Epithelium.
R. J. Ulshafer, C. B. Allen, and M. L. Rubin (1990)
Arch Ophthalmol 108, 113-117
   Abstract »    PDF »
Aluminum and Alzheimer's Disease: Should We Worry?.
R. A. Yokel (1988)
Journal of Pharmacy Practice 1, 118-127
   PDF »
Relationship of Aluminum to Neurocognitive Dysfunction in Chronic Dialysis Patients.
S. M. Sprague, H. L. Corwin, C. M. Tanner, R. S. Wilson, B. J. Green, and C. G. Goetz (1988)
Arch Intern Med 148, 2169-2172
   Abstract »    PDF »
Promotion of tubulin assembly by aluminum ion in vitro.
T. Macdonald, W. Humphreys, and R. Martin (1987)
Science 236, 183-186
   Abstract »    PDF »
Perspectives on the Etiology of Alzheimer's Disease.
H. N. Mozar, D. G. Bal, and J. T. Howard (1987)
JAMA 257, 1503-1507
   Abstract »    PDF »
Etiologic theories of Alzheimer's disease.
M. Schweber (1986)
American Journal of Alzheimer's Disease and Other Dementias 1, 24-31
   Abstract »    PDF »
A Family With Histologically Confirmed Alzheimer's Disease.
L. E. Nee, R. J. Polinsky, R. Eldridge, H. Weingartner, S. Smallberg, and M. Ebert (1983)
Arch Neurol 40, 203-208
   Abstract »    PDF »
Antacid-Induced Calcium Loss.
H. Spencer and L. Kramer (1983)
Arch Intern Med 143, 657-659
   Abstract »    PDF »
Alzheimer's disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons.
D. Perl and A. Brody (1980)
Science 208, 297-299
   Abstract »    PDF »
Aluminum absorption and distribution: effect of parathyroid hormone.
G. Mayor, J. Keiser, D Makdani, and P. Ku (1977)
Science 197, 1187-1189
   Abstract »    PDF »
Dementia: A Brief and Selective Review.
R. D. Terry (1976)
Arch Neurol 33, 1-4
   Abstract »    PDF »
Pulmonary Aluminosis--A Review.
T. L. Guidotti (1975)
Toxicol Pathol 3, 16-18
   PDF »
Alzheimer Degeneration in Down Syndrome: Electrophysiologic Alterations and Histopathologic Findings.
D. R. Crapper, A. J. Dalton, M. Skopitz, J. W. Scott, and V. C. Hachinski (1975)
Arch Neurol 32, 618-623
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)