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Science 27 April 1973:
Vol. 180. no. 4084, pp. 406 - 408
DOI: 10.1126/science.180.4084.406
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Articles

Dystrophic Chicken Muscle: Altered Synaptic Acetylcholinesterase

J. Jedrzejczyk 1, J. Wieckowski 1, T. Rymaszewska 1, and E. A. Barnard 1

1 Departments of Biochemistry and Biochemical Pharmacology, State University of New York, Buffalo 14214

Individual motor endplates in the skeletal muscles of chickens genetically homozygous for muscular dystrophy have been compared with those in normal chickens. Measurements were made there, by specific autoradiographic techniques, of the numbers of total cholinesterase-like molecules and of acetylcholinesterase molecules. The acetylcholinesterase is distinctly decreased at the endplates in dystrophic muscles. The various data available on these muscles are compatible with the concept that a neural factor which determines the synaptic acetylcholinesterase, along with a number of other characters in the muscle cell, is defective in this disorder.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Myogenic defect in acetylcholinesterase regulation in muscular dystrophy of the chicken.
T. Linkhart, G. Yee, and B. Wilson (1975)
Science 187, 549-551
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Science. ISSN 0036-8075 (print), 1095-9203 (online)