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Science 20 April 1973:
Vol. 180. no. 4083, pp. 312 - 315
DOI: 10.1126/science.180.4083.312
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Articles

Somatomedin: Inhibition of Adenylate Cyclase Activity in Subcellular Membranes of Various Tissues

Guy P. E. Tell 1, Pedro Cuatrecasas 1, Judson J. Van Wyk 2, and Raymond L. Hintz 2

1 Department of Pharmacology and Experimental Therapeutics, and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2 Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill 27514

Somatomedin in concentrations between 3 and 20 units per milliliter significantly inhibits the basal activity of adenylate cyclase in crude membrane preparations obtained from homogenates of fat cells, liver, and spleen lymphocytes of the rat, and from chondrocytes and cartilage of chick embryos. The enzyme activity measured in the presence of stimulating hormones (epinephrine, prostaglandin PGE1, parathyroid hormone) is also inhibited in these preparations by somatomedin. These observations may be relevant in a general way to the mechanism of action of growth-prmoting substances and to the processes which normally regulate cell growth.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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G. Rodan, L. Bourret, A Harvey, and T Mensi (1975)
Science 189, 467-469
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The Somatomedins: A New Class of Growth-Regulating Hormones?.
J. J. Van Wyk, L. E. Underwood, R. C. Lister, and R. N. Marshall (1973)
Arch Pediatr Adolesc Med 126, 705-711
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