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Science 13 April 1973:
Vol. 180. no. 4082, pp. 190 - 191
DOI: 10.1126/science.180.4082.190
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Articles

1agr-Hydroxy Derivative of Vitamin D3: A Highly Potent Analog of 1agr,25-Dihydroxyvitamin D3

M. F. Holick 1, E J. Semmler 1, H. K. Schnoes 1, and H. F. Deluca 1

1 Department of Biochemistry, College of Agricultutral and Life Sciences, University of Wisconsin, Madison 53706

The 1agr-hydroxy derivative of vitamin D3 has been chemically synthesized and tested for its biological activity. This analog has comparable biological activity on a weight basis to 1,25-dihydroxyvitamin D3 in the stimulation of intestinal calcium transport and bone calcium mobilization in normnal and anephric rats. Because the 1agr-hydroxy derivative is synthesized from cholesterol, it is easier and less expensive to prepare than 1agr,25-dihydroxy derivative, making it attractive as a drug in the treatment of renal osteodystrophy and hypopara-thyroidism.


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Synthesis of (6-3H)-1alpha-hydroxyvitamin D3 and its metabolism in vivo to (3H)-1alpha,25-dihydroxyvitamin D3.
M. Holick, S. Holick, T Tavela, B Gallagher, H. Schnoes, and H. DeLuca (1975)
Science 190, 576-578
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1-a-Hydroxyvitamin D3 in Chronic Renal Failure: A Potent Analogue of the Kidney Hormone, 1,25-Dihydroxycholecalciferol.
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Pharmacology and Therapeutics of Bone.
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