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Science 30 March 1973:
Vol. 179. no. 4080, pp. 1338 - 1340
DOI: 10.1126/science.179.4080.1338
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Articles

Electrocardiogram Monitoring: Computerized Detection of Ventricular Changes Induced by Drugs

Albert J. Berni 1, Marvin W. Luttges 2, and Donald E. Dick 3

1 Department of Electrical Engineering, University of Colorado, Boulder 80302
2 Department of Aerospace Engineering Sciences, University of Colorado
3 Department of Physical Medicine and Rehabilitation, University of Colorado Medical Center, Denver 80220, and Department of Electrical Engineering, University of Colorado

Cardiac arrhythmia was induced in mice by the injection of ouabain, lidocaine, and diphenylhydantoin. Temporal spreading of ventricular electrocardiographic complexes is shown consistently to follow injection of a cardioactive drug and to precede rhythm disturbances. A computerized monitoring technique based on temporal spreading and waveform distortion should find wide clinical and experimental application.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)