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Science 23 March 1973:
Vol. 179. no. 4079, pp. 1243 - 1246
DOI: 10.1126/science.179.4079.1243
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Articles

Camptothecin Blocks Memory of Conditioned Avoidance in the Goldfish

J. H. Neale 1, P. D. Klinger 1, and B. W. Agranoff 1

1 Mental Health Research Institute and Neurosciences Laboratory, University of Michigan, Ann Arbor 48104

Intracranial injection of 10 to 75 micrograms of camptothecin, a plant alkaloid that blocks RNA synthesis in eucaryotic cells, blocks incorporation of tritiated uridine into RNA in the goldfish brain. Injection of 10 to 50 micrograms of the drug within 1.5 hours of training results in greatly diminished memory, tested 1 week later. Injection of the drug 5 or 24 hours after training produces no measurable effect on retention of the learned response.


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