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Science 16 March 1973:
Vol. 179. no. 4078, pp. 1133 - 1136
DOI: 10.1126/science.179.4078.1133
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Articles

Strychnine- and Pentylenetetrazol-Induced Changes of Excitability in Aplysia Neurons

Manfred R. Klee 1, Donald S. Faber 1, and Wolf-Dieter Heiss 1

1 Max-Planck-Institut für Hirnforschung, Neurobiologische Abteilung, Frankfurt/M.-Niederrad, West Germany, and Neurosensory Laboratory, Department of Physiology, State University of New York at Buffalo, Buffalo 14215

In Aplysia neurons isolated from their synaptic input strychnine induces doublet discharges associated in voltage clamp with a decrease in the threshold for the inward current and a reduction and delayed onset of the outward current. Pentylenetetrazol causes oscillations and bursting behavior in normally silent cells together with an increased inactivation of the delayed outward current and induced or enhanced anomalous rectification.


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