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Science 9 March 1973:
Vol. 179. no. 4077, pp. 1000 - 1001
DOI: 10.1126/science.179.4077.1000
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Articles

Conversion of Thyroxine to Triiodothyronine by Cultured Human Cells

Kenneth Sterling 1, Milton A. Brenner 1, and Victor F. Saldanha 1

1 Department of Medicine, Columbia University College of Physicians and Surgeons, and Veterans Administration Hospital, Bronx, New York 10468

Human liver and kidney cells convert 6 to 10 percent of added thyroxine to triiodothyronine in vitro at 37°C. This extent of conversion is ten times greater than that in control studies with killed cells. Conversion is evident within 10 minutes and appears to be maximal within 1 hour. Greater net triiodothyronine formation results if greater amounts of exogenous thyroxine are added to the system, with no plateau evident even at very high thyroxine concentrations. The addition of high concentrations of nonradioactive triiodothyronine resulted in no evident inhibition of the conversion.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Thyroidal and Peripheral Production of Thyroid Hormones: Review of Recent Findings and Their Clinical Implications.
M. SCHIMMEL and R. D. UTIGER (1977)
Ann Intern Med 87, 760-768
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