Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 2 March 1973:
Vol. 179. no. 4076, pp. 897 - 899
DOI: 10.1126/science.179.4076.897
Prev | Table of Contents | Next

Articles

Amine Metabolites in Human Cerebrospinal Fluid: Effects of Cord Transection and Spinal Fluid Block

Robert M. Post 1, Frederick K. Goodwin 1, Edna Gordon 1, and Donald M. Watkin 2

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
2 Veterans Administration Hospital, West Roxbury, Massachusetts 02132

Patients with spinal cord transection had normal concentrations of 5-hydroxyindoleacetic acid and low concentrations of 3-methoxy-4-hydroxyphenyl glycol in lumbar cerebrospinal fluid. The presence or absence of spinal fluid block in these patients did not affect concentrations of either amine metabolite. However, the concentration of homovanillic acid was lower in patients with spinal fluid block than in those without block. The results suggest that the spinal cord contributes to concentrations of 3-methoxy-4-hydroxyphenyl glycol and possibly 5-hydroxyindoleacetic acid, but contributes little to that of homovanillic acid in the lumbar spinal fluid of man.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reduced Brain Delivery of Homovanillic Acid to Cerebrospinal Fluid During Human Aging.
S. I. Rapoport, M. B. Schapiro, and C. May (2004)
Arch Neurol 61, 1721-1724
   Abstract »    Full Text »    PDF »
Dopamine Metabolism and Disposition in Schizophrenic Patients: Studies Using Debrisoquin.
J. W. Maas, S. A. Contreras, E. Seleshi, and C. L. Bowden (1988)
Arch Gen Psychiatry 45, 553-559
   Abstract »    PDF »
Carcinoid Carcinomatous Meningitis.
R. A. NAGOURNEY, R. HEDAYA, M. LINNOILA, and P. S. SCHEIN (1985)
Ann Intern Med 102, 779-782
   Abstract »    PDF »
Reliability of Norepinephrine and Major Monoamine Metabolite Measurements in CSF of Schizophrenic Patients.
M. Linnoila, P. T. Ninan, M. Scheinin, R. N. Waters, W.-H. Chang, J. Bartko, and D. P. van Kammen (1983)
Arch Gen Psychiatry 40, 1290-1294
   Abstract »    PDF »
Aberrant Monoamine Metabolite Levels in CSF and Family History of Schizophrenia: Their Relationships in Schizophrenic Patients.
G. C. Sedvall and B. Wode-Helgodt (1980)
Arch Gen Psychiatry 37, 1113-1116
   Abstract »    PDF »
Memory impairment in Korsakoff's psychosis: a correlation with brain noradrenergic activity.
W. McEntee and R. Mair (1978)
Science 202, 905-907
   Abstract »    PDF »
Effects of a Dopamine Agonist Piribedil in Depressed Patients: Relationship of Pretreatment Homovanillic Acid to Antidepressant Response.
R. M. Post, R. H. Gerner, J. S. Carman, J. C. Gillin, D. C. Jimerson, F. K. Goodwin, and W. E. Bunney Jr (1978)
Arch Gen Psychiatry 35, 609-615
   Abstract »    PDF »
Clinical and Biochemical Heterogeneity of Depressive Disorders.
J. W. MAAS (1978)
Ann Intern Med 88, 556-563
   Abstract »    PDF »
Homovanillic Acid and 5-Hydroxyindoleacetic Acid Cerebrospinal Fluid Levels: A Study With and Without Probenecid Administration of Their Relationship to the State of Consciousness After Head Injury.
C. J. Vecht, T. C.A.M. van Woerkom, A. W. Teelken, and J. M. Minderhoud (1975)
Arch Neurol 32, 792-797
   Abstract »    PDF »
Time-dependent effects of phenothiazines on dopamine turnover in psychiatric patients.
R. Post and F. Goodwin (1975)
Science 190, 488-489
   Abstract »    PDF »
Cerebrospinal Fluid Amine Metabolites in Acute Schizophrenia.
R. M. Post, E. Fink, W. T. Carpenter Jr, and F. K. Goodwin (1975)
Arch Gen Psychiatry 32, 1063-1069
   Abstract »    PDF »
Overview of Recent Research in Depression: Integration of Ten Conceptual Models Into a Comprehensive Clinical Frame.
H. S. Akiskal and W. T. McKinney Jr. (1975)
Arch Gen Psychiatry 32, 285-305
   Abstract »    PDF »
5-Hydroxyindoleacetic Acid in the Lumbar Fluid: A Specific Indicator of Spinal Cord Injury.
M. Bulat, Z. LackoviCacute, M. JakupCcaroneviCcaron, and I. Damjanov (1974)
Science 185, 527-528
   Abstract »    PDF »
Central Dopamine Turnover in Schizophrenic Syndromes.
M. B. Bowers Jr. (1974)
Arch Gen Psychiatry 31, 50-54
   Abstract »    PDF »
Effects of Amitriptyline and Imipramine on Amine Metabolites in the Cerebrospinal Fluid of Depressed Patients.
R. M. Post and F. K. Goodwin (1974)
Arch Gen Psychiatry 30, 234-239
   Abstract »    PDF »
Dopamine-beta-Hydroxylase: Evidence for Increased Activity in Sympathetic Neurons during Psychotic States.
S. Rosenblatt, W. P. Leighton, and J. D. Chanley (1973)
Science 182, 923-924
   Abstract »    PDF »
Central Norepinephrine Metabolism in Affective Illness: MHPG in the Cerebrospinal Fluid.
R. M. Post, E. K. Gordon, F. K. Goodwin, and W. E. Bunney Jr. (1973)
Science 179, 1002-1003
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)