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Science 23 February 1973:
Vol. 179. no. 4075, pp. 816 - 817
DOI: 10.1126/science.179.4075.816
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Articles

Tremor and Involuntary Movements in Monkeys: Effect of L-Dopa and of a Dopamine Receptor Stimulating Agent

M. Goldstein 1, A. F. Battista 2, T. Ohmoto 2, B. Anagnoste 3, and K. Fuxe 4

1 Neurochemistry Laboratory, Department of Psychiatry, New York University Medical Center, New York 10016
2 Department of Neurosurgery, New York University Medical Center
3 Neurochemistry Laboratory, Department of Psychiatry, New York University Medical Center
4 Department of Histology, Karolinska Institute, Stockholm, Sweden

Either L-dopa, in combination with 1-agr-methyldopa hydrazine (MK-486), or 1-(2''-pyrimidyl)-4-piperonylpiperazine, an agent that stimulates dopamine receptors, relieves surgically induced tremor in monkeys and concomitantly evokes involuntary movements. These results indicate that tremor and involuntary movements are associated with a common mechanism and that the activity of the dopamine receptors is involved in the regulation of these dysfunctions.


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