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Science 16 February 1973:
Vol. 179. no. 4074, pp. 698 - 700
DOI: 10.1126/science.179.4074.698
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Articles

Soluble Membrane Antigens of Lip and Cervical Carcinomas: Reactivity with Antibody for Herpesvirus Nonvirion Antigens

Ariel C. Hollinshead 1 and Giulio Tarro 2

1 Laboratory for Virus and Cancer Research, George Washington University Medical Center, Washington, D.C. 20037
2 Virologia Oncologica, Istituto di Clinica Medica 1, Università di Napoli, Policlinico, Nàpoli 80138, Italy

With the use of antibody for herpesvirus nonvirion antigens (not structural components of the virus) complement fixing reactivity has been shown for soluble membrane antigens separated from lip and cervical carcinomas but not for similar extracts from normal vaginal tissue or intestinal carcinoma. Neither the serum obtained from the guinea pig before hyperimmunization with the herpesvirus nonvirion antigen nor the antiserum of guinea pigs immunized with comparable uninfected cell extracts reacted with these tumor soluble membrane antigens. Since the above soluble membrane antigens could be specific markers for the presence of virus genome within the tumor cells, the findings could support an etiological role of herpesvirus in selected human malignancies.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Demonstration of the Oncogenic Potential of Herpes Simplex Viruses and Human Cytomegalovirus.
F. Rapp and J.-L. H. Li (1974)
Cold Spring Harb Symp Quant Biol 39, 747-763
   Abstract »    PDF »
Antibodies to Herpesvirus Nonvirion Antigens in Squamous Carcinomas.
A. C. Hollinshead, O. Lee, P. B. Chretien, J. L. Tarpley, W. E. Rawls, and E. Adam (1973)
Science 182, 713-715
   Abstract »    PDF »
Antibody to HSV-2 Induced Tumor Specific Antigens in Serums from Patients with Cervical Carcinoma.
L. Aurelian, B. Schumann, R. L. Marcus, and H. J. Davis (1973)
Science 181, 161-164
   Abstract »    PDF »


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