Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 16 February 1973:
Vol. 179. no. 4074, pp. 683 - 685
DOI: 10.1126/science.179.4074.683
Prev | Table of Contents | Next

Articles

Aqueous Central Cavity in Aspartate Transcarbamylase from Escherichia coli

D. R. Evans 1, S. G. Warren 1, B. F. P. Edwards 1, C. H. McMurray 1, P. H. Bethge 1, D. C. Wiley 1, and W. N. Lipscomb 1

1 Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138

A three-dimensional x-ray diffraction study of aspartate transcarbamylase to 5.5-angstrom resolution, with the aid of four isomorphous heavy atom derivatives, indicates the presence of a central aqueous cavity approximating an oblate spheroid about 25 by 50 by 50 angstroms in dimension, within a molecule about 90 by 110 by 110 angstroms in largest dimensions.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)