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Science 9 February 1973:
Vol. 179. no. 4073, pp. 584 - 585
DOI: 10.1126/science.179.4073.584
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Articles

Amphotericin B Methyl Ester Hydrochloride and Amphotericin B: Comparative Acute Toxicity

G. R. Keim Jr. 1, J. W. Poutsiaka 1, J. Kirpan 1, and C. H. Keysser 1

1 Squibb Institute for Medical Research, New Brunswick, New Jersey 08903

In single-dose parenteral studies with mice and dogs, the methyl ester hydrochloride of amphotericin B proved to be significantly less toxic than the parent compound, especially to the kidney.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neurotoxicity of Amphotericin B Methyl Ester in.
W. G. Ellis, E. Bencken, R. A. LeCouteur, J. R. Barbano, B. M. Wolfe, and M. B. Jennings (1988)
Toxicol Pathol 16, 1-9
   Abstract »    PDF »
Mucormycosis.
R. I. LEHRER, D. H. HOWARD, P. S. SYPHERD, J. E. EDWARDS, G. P. SEGAL, and D. J. WINSTON (1980)
Ann Intern Med 93, 93-108
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)