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Science 9 February 1973:
Vol. 179. no. 4073, pp. 579 - 580
DOI: 10.1126/science.179.4073.579
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Articles

Amyotrophic Lateral Sclerosis: Effect of Serum on Anterior Horn Cells in Tissue Culture

Frederick Wolfgram 1 and Lawrence Myers 1

1 Department of Neurology, Reed Neurological Research Center, University of California, School of Medicine, Los Angeles 90024

A high proportion of diluted serums of patients with amyotrophic lateral sclerosis were toxic to the anterior horn cells of the mouse in tissue culture. This is not a general cytotoxicity, since apparently only the neurons were killed. Serums from other degenerative neurological diseases were inactive.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effect of High-Dose Intravenous Immunoglobulin on Amyotrophic Lateral Sclerosis and Multifocal Motor Neuropathy.
M. C. Dalakas, D. P. Stein, C. Otero, E. Sekul, E. J. Cupler, and S. McCrosky (1994)
Arch Neurol 51, 861-864
   Abstract »    PDF »
A Double-blind Study of the Effectiveness of Cyclosporine in Amyotrophic Lateral Sclerosis.
S. H. Appel, S. S. Stewart, V. Appel, Y. Harati, W. Mietlowski, W. Weiss, and G. W. Belendiuk (1988)
Arch Neurol 45, 381-386
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Amyotrophic Lateral Sclerosis: Associated Clinical Disorders and Immunological Evaluations.
S. H. Appel, V. Stockton-Appel, S. S. Stewart, and R. H. Kerman (1986)
Arch Neurol 43, 234-238
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Plasma Exchange in Neurologic Diseases.
R. P. Lisak (1984)
Arch Neurol 41, 654-657
   Abstract »    PDF »
Plasmapheresis With Immunosuppression in Amyotrophic Lateral Sclerosis.
J. Kelemen, W. Hedlund, J. B. Orlin, E. M. Berkman, and T. L. Munsat (1983)
Arch Neurol 40, 752-753
   Abstract »    PDF »
Plasma Exchange Ineffective in Amyotrophic Lateral Sclerosis.
V. Silani, G. Scarlato, G. Valli, and M. Marconi (1980)
Arch Neurol 37, 511-513
   Abstract »    PDF »
Amyotrophic Lateral Sclerosis Sera Applied to Cultured Motor Neurons.
M. S. Horwich, W. K. Engel, and P. B. Chauvin (1974)
Arch Neurol 30, 332-333
   Abstract »    PDF »
Amyotrophic Lateral Sclerosis: Summary of a Conference.
G. M. MckHann and R. T. Johnson (1973)
Science 180, 221-222
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Science. ISSN 0036-8075 (print), 1095-9203 (online)