Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 2 February 1973:
Vol. 179. no. 4072, pp. 492 - 493
DOI: 10.1126/science.179.4072.492
Prev | Table of Contents | Next

Articles

Epstein-Barr Virus: Detection of Genome in Somatic Cell Hybrids of Burkitt Lymphoblastoid Cells

Ronald Glaser 1 and Meihan Nonoyama 2

1 Department of Microbiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033
2 Department of Bacteriology and Immunology, School of Medicine, University of North Carolina, Chapel Hill 27514

Somatic cell hybrids of Burkitt lymphoblastoid cells, from which Epstein-Barr virus can be recovered, were examined for the presence of virus DNA by DNA-RNA hybridization. Four clones of hybrid cells, each negative for virus antigens by immunofluorescence, contained virus DNA in varying genomic equivalents. The number of virus genome equivalents increased in the hybrid cells after induction of virus with iododeoxyuridine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transformation Induced by Epstein-Barr Virus and the Role of the Nuclear Antigen.
G. Klein, J. Luka, and J. Zeuthen (1980)
Cold Spring Harb Symp Quant Biol 44, 253-261
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)