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Science 5 January 1973:
Vol. 179. no. 4068, pp. 86 - 88
DOI: 10.1126/science.179.4068.86
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Articles

Photoreactivation of Ultraviolet-Induced Chromosomal Aberrations

H. Gaston Griggs 1 and Michael A. Bender 1

1 Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Ultraviolet induces only chromatid-type aberrations in synchronized G1 V-79 Chinese hamster and A8W243 Xenopus tissue culture cells. Posttreatment with white light prevents expression of most potential aberrations in the A8 toad cell, which possesses a photoreactivation enzyme. We conclude that the major ultraviolet-induced DNA lesion leading to chromosomal aberrations is the pyrimidine dimer.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)