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Science 5 January 1973:
Vol. 179. no. 4068, pp. 82 - 84
DOI: 10.1126/science.179.4068.82
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Articles

Insulin Release by Emiocytosis: Demonstration with Freeze-Etching Technique

L. Orci 1, M. Amherdt 1, F. Malaisse-Lagae 1, C. Rouiller 1, and A. E. Renold 1

1 Institutes of Histology and Clinical Biochemistry, University of Geneva, 1211 Geneva 4, Switzerland

The technique of freeze-etching for electron microscopy applied to isolated islets of Langerhans has permitted a successful evaluation of emiocytotic events on the cell surface. The frequency of these events in stimulated cells suggests that emiocytosis represents a significant mechanism for insulin release.


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