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Science 22 December 1972: Vol. 178. no. 4067, pp. 1288 - 1290 DOI: 10.1126/science.178.4067.1288
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Articles
Recognition of Cancer in vivo by Nuclear Magnetic Resonance
Irwin D. Weisman 1,
Lawrence H. Bennett 1,
Louis R. Maxwell Sr. 2,
Mark W. Woods 3, and
Dean Burk 3
1 Institute for Materials Research, National Bureau of Standards, Gaithersburg, Maryland 20760
2 3506 Leland Street, Chevy Chase, Maryland 20015
3 National Cancer Institute, Bethesda, Maryland 20014
Pulsed nuclear magnetic resonance has been used to differentiate in vivo between normal mouse tail tissue and a malignant transplanted melanoma, S91, located on the tail. The tumor displayed a nuclear (proton) spin-lattice relaxation time of 0.7 second contrasted with the simultaneously measured normal tail tissue relaxation time of 0.3 second.
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