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Science 15 December 1972:
Vol. 178. no. 4066, pp. 1211 - 1213
DOI: 10.1126/science.178.4066.1211
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Articles

Inhibition of Sperm-Egg Interaction by Specific Antibody

C. A. Shivers 1, A. B. Dudkiewicz 1, L. E. Franklin 2, and E. N. Fussell 2

1 Department of Zoology, University of Tennessee, Knoxville 37916
2 Delta Regional Primate Research Center, Tulane University, Covington, Louisiana 70433

Treatment of hamster ova, in vitro, with ovary specific antibody interferes with sperm-egg interaction by inhibiting sperm attachment to the zona pellucida and subsequent zona penetration. This inhibition results from precipitation of the zona by the specific antibody.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antibodies to human ZP3 induce reversible contraception in transgenic mice with `humanized' zonae pellucidae.
S. Greenhouse, P. E. Castle, and J. Dean (1999)
Hum. Reprod. 14, 593-600
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Sperm-egg interaction: evidence for boar sperm plasma membrane receptors for porcine zona pellucida.
R. Peterson, L Russell, D Bundman, and M Freund (1980)
Science 207, 73-74
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Autoantibodies to zona pellucida: a possible cause for infertility in women.
C. Shivers and B. Dunbar (1977)
Science 197, 1082-1084
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