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Science 8 December 1972:
Vol. 178. no. 4065, pp. 1104 - 1106
DOI: 10.1126/science.178.4065.1104
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Articles

Cat Hemoglobin: pH-Dependent Cooperativity of Oxygen Binding

Marit N. Hamilton 1 and Stuart J. Edelstein 1

1 Section of Biochemistry and Molecular Biology, Cornell University, Ithaca, New York 14850

Cat hemoglobin has a lower cooperativity and oxygen affinity than most mammalian hemoglobins. In contrast to the usual invariance of cooperativity with pH, a rise in cooperativity with pH is predicted by the allosteric model for low-affinity hemoglobins. Such a pH-dependent cooperativity for cat hemoglobin has been found.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)