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Science 8 December 1972:
Vol. 178. no. 4065, pp. 1098 - 1100
DOI: 10.1126/science.178.4065.1098
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Articles

Type C Virus from Cell Cultures of Chemically Induced Rat Hepatomas

I. Bernard Weinstein 1, Ronald Gebert 1, Ulrike C. Stadler 1, Jan M. Orenstein 1, and Richard Axel 1

1 Institute of Cancer Research and Departments of Medicine and Pathology, Columbia University College of Physicians and Surgeons, New York 10032

Type C RNA viruses are present in cell cultures from transplantable and primary hepatomas induced by aromatic amine carcinogens. Virus yield was markedly enhanced by treating the cells with bromodeoxyuridine. Preparations of rat hepatoma-associated virus obtained from cultures treated with this compound were deficient in DNA polymerase activity.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)