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Science 1 December 1972:
Vol. 178. no. 4064, pp. 999 - 1001
DOI: 10.1126/science.178.4064.999
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Articles

Calcitonin Receptors of Kidney and Bone

S. J. Marx 1, C. J. Woodard 1, and G. D. Aurbach 1

1 Section on Mineral Metabolism, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014

Receptors for calcitonin, determined by activation of adenylate cyclase, were found in a distribution among zones of the kidney distinct from that of receptors for parathyroid hormone or vasopressin. Competitive binding studies showed that the receptors for calcitonin are similar in kidney and bone and that their high apparent affinity for salmon calcitonin accounts in part for the high biological potency in vivo of salmon calcitonin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Procalcitonin and the Calcitonin Gene Family of Peptides in Inflammation, Infection, and Sepsis: A Journey from Calcitonin Back to Its Precursors.
K. L. Becker, E. S. Nylen, J. C. White, B. Muller, and R. H. Snider Jr. (2004)
J. Clin. Endocrinol. Metab. 89, 1512-1525
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Interaction of calcitonin and calcitonin gene-related peptide at receptor sites in target tissues.
D Goltzman and J Mitchell (1985)
Science 227, 1343-1345
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Current Concepts of Bone Metabolism.
L. LUTWAK, F. R. SINGER, and M. R. URIST (1974)
Ann Intern Med 80, 630-644
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