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Science 1 December 1972:
Vol. 178. no. 4064, pp. 986 - 988
DOI: 10.1126/science.178.4064.986
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Articles

Antigens Specific for Human Lymphocytic and Myeloid Leukemia Cells: Detection by Nonhuman Primate Antiserums

Richard S. Metzgar 1, T. Mohanakumar 1, and Donald S. Miller 1

1 Departments of Microbiology and Immunology and of Medicine, Duke University Medical Center, Durham, North Carolina 27710, and Yerkes Primate Research Center, Emory University, Atlanta, Georgia

Primate antiserums to human leukemia cells can detect antigens specific for lymphocytic leukemia cells or antigens present on certain myeloid leukemia cells. The antigen specific for lymphocytic leukemia cells is destroyed by treatment with neuraminidase or trypsin. Tryptic digests of lymphocytic leukemia cells contain the antigen, which has a high molecular weight.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunotherapy and Human Tumor Immunology.
J. L. FAHEY, S. BROSMAN, R. C. OSSORIO, C. O'TOOLE, and J. ZIGHELBOIM (1976)
Ann Intern Med 84, 454-465
   Abstract »    PDF »
Cytophilic Antibodies in Man.
M. S. MITCHELL, M. B. MOKYR, G. T. ASPNES, and S. McINTOSH (1973)
Ann Intern Med 79, 333-339
   Abstract »    PDF »


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