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Science 24 November 1972:
Vol. 178. no. 4063, pp. 866 - 867
DOI: 10.1126/science.178.4063.866
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Articles

Bone Marrow-Derived Lymphoid Cells (B Cells): Functional Depletion with Cobra Factor and Fresh Serum

Nelson L. Levy 1, David W. Scott 1, and Ralph Snyderman 2

1 Division of Immunology, Duke University Medical Center, Durham, North Carolina 27710
2 Department of Medicine, Duke University Medical Center

Treatment of rat spleen cells with cobra factor and fresh rat serum provided a simple, rapid means of functionally eliminating complement receptor lymphocytes. Cells able to differentiate into plaque-forming cells in a syngeneic, irradiated host were diminished, but cells able to induce a graft-versus-host reaction were not diminished. There was no effect on plaque-forming cells from an immune spleen.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)