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Science 24 November 1972:
Vol. 178. no. 4063, pp. 860 - 862
DOI: 10.1126/science.178.4063.860
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Articles

Genetic Mapping of a Murine Leukemia Virus-Inducing Locus of AKR Mice

Wallace P. Rowe 1, Janet W. Hartley 1, and Theodore Bremner 2

1 Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014
2 Department of Botany, Howard University, Washington, D.C. 20001

The chromosomal location of one of the two murine leukemia virus-inducing loci of AKR mice has been determined. The locus, which appears to be the integrated genome of the virus, is designated Akv-1, and is on linkage group 1, 12 map units from Gpi-1, with gene order c-Gpi-1-Akv-1. This identification of a closely linked gene whose phenotype is independent of virus expression should facilitate analysis of the biologic importance of the Akv-1 locus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Retrotransposons Influence the Mouse Transcriptome: Implication for the Divergence of Genetic Traits.
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Structure and Infectivity of Integrated Murine Leukemia Virus DNA.
D. R. Lowy, E. Rands, S. K. Chattopadhyay, and G. L. Hager (1980)
Cold Spring Harb Symp Quant Biol 44, 1143-1151
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Genetic linkage of C3H/HeJ and BALB/c endogenous ecotropic C-type viruses to phosphoglucomutase-1 on chromosome 5.
J. Ihle, D. Joseph, and J. Domotor Jr (1979)
Science 204, 71-73
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Qualitative and Quantitative Studies of AKR-type Murine Leukemia Virus Sequences in Mouse DNA.
S. K. Chattopadhyay, D. R. Lowy, N. M. Teich, A. S. Levine, and W. P. Rowe (1974)
Cold Spring Harb Symp Quant Biol 39, 1085-1101
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Genetic Control of the Expression of Murine Leukemia Virus Proteins in Tissues of Normal, Young Adult Mice.
M. Strand, F. Lilly, and J. T. August (1974)
Cold Spring Harb Symp Quant Biol 39, 1117-1122
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Differential Cellular Regulation of Three Distinct Classes of Type C RNA Viruses Endogenous to Mouse Cells.
S. A. Aaronson and J. R. Stephenson (1974)
Cold Spring Harb Symp Quant Biol 39, 1129-1137
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Segregation of Loci for C-Type Virus Induction in Strains of Mice with High and Low Incidence of Leukemia.
J. R. Stephenson and S. A. Aaronson (1973)
Science 180, 865-866
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Location of the Second Gene Required for Expression of the Leukemia-Associated Mouse Antigen GIX.
E. Stockert, H. Sato, K. Itakura, E. A. Boyse, L. J. Old, and J. J. Hutton (1972)
Science 178, 862-863
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