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Science 17 November 1972:
Vol. 178. no. 4062, pp. 753 - 755
DOI: 10.1126/science.178.4062.753
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Articles

Curare and Pancuronium Compared: Effects on Previously Undepressed Mammalian Myoneural Junctions

Annibal Galindo 1

1 Department of Anesthesiology and Anesthesia Research Center, University of Washington School of Medicine, Seattle 98195

Curare and pancuronium have multiple effects on previously undepressed rat diaphragm; these include depression of transmitter output and prolongation of the refractory period of prejunctional structures. The effect of curare on motor nerve terminals is greater than that of pancuronium. Both drugs depress postjunctional receptors; but curare, in addition, raises the threshold for the generation of muscle action potentials. In addition, these results raise questions about the validity of statistical methods used to calculate transmitter output.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)