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Science 10 November 1972:
Vol. 178. no. 4061, pp. 639 - 640
DOI: 10.1126/science.178.4061.639

Articles

Mitochondrial Polyriboadenylate Polymerase: Relative Lack of Activity in Hepatomas

Samson T. Jacob 1, Daniel G. Schindler 1, and Harold P. Morris 2

1 Physiological Chemistry Laboratories, Massachusetts Institute of Technology, Cambridge 02139
2 Department of Biochemistry, Howard University, Washington, D.C. 20001

An enzyme that polymerizes adenylate residues from adenosine triphosphate was prepared from rat liver mitochondria and compared to similar preparations from the mitochondria of three hepatomas. Enzyme activity in the hepatomas was only 1 to 2 percent of that in normal liver.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)