Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 November 1972:
Vol. 178. no. 4061, pp. 633 - 634
DOI: 10.1126/science.178.4061.633
Prev | Table of Contents | Next

Articles

Cholesterol Dissolution Rate in Micellar Bile Acid Solutions: Retarding Effect of Added Lecithin

William I. Higuchi 1, Sompol Prakongpan 1, Vijay Surpuriya 1, and Fudah Young 1

1 College of Pharmacy, University of Michigan, Ann Arbor 48104

In vitro studies on the dissolution rate of cholesterol monohydrate crystals in micellar bile acid solutions showed that the addition of lecithin decreases the dissolution rate even though lecithin increases the equilibrium solubility of cholesterol in these solutions. The reduction in rates caused by lecithin was attributed to a large crystal-solution interfacial barrier. An effective permeability coefficient for the interfacial barrier was calculated to be around 1.5 x 10-5 centimeter per second for the transport of cholesterol molecules.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)