Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 3 November 1972:
Vol. 178. no. 4060, pp. 505 - 507
DOI: 10.1126/science.178.4060.505
Prev | Table of Contents | Next

Articles

Detergent Effects on a Reverse Transcriptase Activity and on Inhibition by Rifamycin Derivatives

Frances M. Thompson 1, Louis J. Libertini 1, Urs R. Joss 1, and Melvin Calvin 1

1 Laboratory of Chemical Biodynamics, University of California, Berkeley 94720

A reverse transcriptase activity, extracted from virus-transformed cells, is activated by very low concentrations of nonionic detergents. These same detergents also significantly reduce the effectiveness of certain rifamycin derivatives as inhibitors of the polymerase activity when the detergents are present at micelle-forming concentrations.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)