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Science 27 October 1972:
Vol. 178. no. 4059, pp. 419 - 421
DOI: 10.1126/science.178.4059.419
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Articles

Coherin: A New Peptide of the Bovine Neurohypophysis with Activity on Gastrointestinal Motility

Irving Goodman 1 and Robert B. Hiatt 2

1 Department of Biochemistry
2 Department of Surgery, Columbia University, College of Physicians and Surgeons, New York 10032

A factor with potent activity in the regulation of mammalian gastrointestinal motor function has been isolated from the bovine posterior pituitary gland by a process allowing minimal dissociation of neurophysin-bound complexes and the separation of free unbound peptides. This substance alters the frequency, amplitude, rhythm, and duration of peristaltic contraction.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Peptide Treatment of Postgastrectomy Obstruction.
R. B. Hiatt and I. Goodman (1976)
Arch Surg 111, 997-999
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Science. ISSN 0036-8075 (print), 1095-9203 (online)