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Science 6 October 1972:
Vol. 178. no. 4056, pp. 65 - 67
DOI: 10.1126/science.178.4056.65
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Articles

Cell Culture on Artificial Capillaries: An Approach to Tissue Growth in vitro

Richard A. Knazek 1, Pietro M. Gullino 1, Peter O. Kohler 2, and Robert L. Dedrick 3

1 Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
2 Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health
3 Division of Research Services, Biomedical Engineering and Instrumentation Branch, National Institutes of Health

Artificial capillaries perfused with culture medium provide a matrix in which cells can attain tissue-like densities in vitro. Products secreted into the medium can be measured as indicators of cell function or may be recovered for other purposes without disturbing the culture.


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